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WELLNESS

NAD+ and Sermorelin are very different treatments.

NAD+ is a coenzyme involved in cellular metabolism. Sermorelin is a peptide that stimulates the body’s own growth-hormone release. Explore what each does, how it is taken, what the research supports and where the evidence is still limited.

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Learn how they differ

Start with the biology.

NAD+

A coenzyme your cells use in energy and redox reactions. The biology is well established. Claims that NAD+ injections, sprays or tablets broadly improve energy, cognition, recovery or aging are much less established in human clinical-outcomes research.

Sermorelin

A peptide analog of GHRH, a naturally occurring hormone that signals the pituitary gland to release growth hormone. Sermorelin is not HGH. Adult wellness use of compounded sermorelin is not an FDA-approved indication.

For men & womenInjection

NAD+

NAD+ Injection

Active ingredients: NAD+

Compounded injectable NAD+, a cellular coenzyme involved in energy metabolism.

Why choose it

For people who prefer direct administration and are comfortable with injections.

$249 per month

  • Monthly $249
  • 3-month supply $597
  • 6-month supply $997
  • 12-month supply $1,897

No membership fee · No clinician fee · Free shipping

Start Intake (opens in a new tab)Learn More about NAD+ Injection
For men & womenInjection

Sermorelin

Sermorelin Injection

Active ingredients: Sermorelin

An injectable GHRH-analog peptide that stimulates the pituitary to release more of the body's own growth hormone.

Why choose it

For people considering sermorelin who are comfortable with injection, the route with the clearest traditional pharmacologic rationale for a peptide medication.

$259 per month

  • Monthly $259
  • 3-month supply $597
  • 6-month supply $997
  • 12-month supply $1,897

No membership fee · No clinician fee · Free shipping

Start Intake (opens in a new tab)Learn More about Sermorelin Injection

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AT A GLANCE

NAD+ and sermorelin work in different ways

 

NAD+

Sermorelin

What it is

A coenzyme every cell uses to make energy

A peptide that mimics the hormone that signals growth-hormone release

What it targets

Cellular energy and repair pathways

The pituitary gland and your own growth-hormone release

Well established

Its central role in metabolism; supplements can raise NAD-related markers

It stimulates growth-hormone release in human studies

Still uncertain

Benefits for energy, aging or wellness outcomes; no outcome trials of injected NAD+

Benefits for muscle, fat loss, sleep or aging in healthy adults

People sometimes discuss NAD+ when their interest is cellular energy and healthy aging, and sermorelin when their interest is the growth-hormone axis. They are not substitutes for one another, and neither is proven to reverse aging.

Sources: NAD+ review (Ageing Res Rev 2026); GHRH(1-29) study (Peptides 1985).

NAD+

Cellular coenzyme · Injection · Nasal spray · Tablet

  • A cellular coenzyme involved in energy metabolism and many biochemical reactions.
  • Available as injection, nasal spray and tablet.
  • People seek NAD+ wellness treatment for energy, recovery and healthy-aging goals, but clinical evidence for broad wellness outcomes remains limited.

NAD+ is a molecule involved in cellular energy metabolism, redox reactions, DNA repair and many other biological processes. Interest in NAD+ has grown around energy, recovery and healthy-aging goals.

The biology is real. The wellness outcome evidence is still developing. Human studies of NAD+ precursors show biological effects, but broad claims about energy, longevity or anti-aging are not firmly established, and direct clinical evidence for injected NAD+ itself remains limited.

Explore NAD+

Sermorelin

Growth-hormone signaling · Injection · ODT

  • A synthetic growth hormone-releasing hormone analog that stimulates the pituitary to release growth hormone.
  • Available as injection and ODT.
  • People may explore it for sleep, recovery, body-composition or healthy-aging goals, but these adult wellness uses are not FDA-approved and the evidence is less established than for approved endocrine indications.

Sermorelin is a synthetic analog of growth hormone-releasing hormone. Rather than supplying growth hormone directly, it signals the pituitary to release more of the body’s own growth hormone.

Adult wellness use is not an FDA-approved indication. People may explore sermorelin around recovery, sleep, body composition or healthy-aging goals, but expectations should be realistic and clinician-guided.

Explore Sermorelin

HOW IT WORKS

From choosing your treatment to delivery at your door.

  1. Explore your options Compare treatments, formats and pricing.
  2. Complete your secure intake Share your health history, choose the treatment you want to pursue and place a payment method on file.
  3. Clinical review A licensed clinician reviews your information and determines whether treatment is appropriate.
  4. Approved, fulfilled and shipped If prescribed, your authorization is completed, the prescription moves to pharmacy fulfillment and your medication ships to you.
  5. Ongoing support Use your patient portal for clinical communication and reach Avono support for order and account questions.
See exactly how it works

THE RESEARCH

What the studies measured.

Research on the medicines behind these treatments, including exactly what was studied. Study results describe the products and doses tested. They are not a prediction for any one person or for a compounded formulation.

NAD+: state of the evidence

What the study found
Evidence still developing
Who was studied
33 human intervention studies
What it means
NAD+ plays a central role in cellular energy metabolism. Human research on supplementation is growing, but evidence for broad wellness or anti-aging outcomes remains developing.
Important context
The review found no eligible outcomes trials of intravenous or intramuscular NAD+ itself for anti-aging or wellness uses. NAD-related interventions, including precursors · Varied across studies

Sermorelin: how it works

What the study found
GHRH analog
Who was studied
Human studies of growth-hormone release
What it means
Sermorelin is a GHRH analog designed to stimulate the body's own growth-hormone release. Evidence for broad adult wellness outcomes is more limited than evidence for its underlying endocrine mechanism.
Important context
Human studies show sermorelin stimulates growth-hormone release. That is not proof of muscle, fat-loss, sleep or anti-aging benefits. GHRH(1-29), sermorelin

Related reading

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