Tadalafil + Pycnogenol ODT
A dissolving compounded tablet pairing longer-acting tadalafil with Pycnogenol.
Active ingredients: Tadalafil + Pycnogenol
From $60 for 6 doses
- 6 doses $60
- 12 doses $99
- 18 doses $129
No membership fee · No clinician fee · Free shipping
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Tadalafil is an FDA-approved ED medication in standard tablet formulations. This tadalafil + Pycnogenol compounded ODT is not FDA-approved as a combination product.
What it does
Tadalafil is a PDE5 inhibitor with a longer duration of action. Standard tadalafil data show erectile-function effects can persist for up to 36 hours. Pycnogenol is a botanical extract; its added benefit in this exact formula is less established.
What's in it
Tadalafil
- What it is
- Longer-acting PDE5 inhibitor.
- Hormone?
- Not a hormone.
- Why it's here
- Supports erectile response during sexual stimulation and can provide a longer timing window.
Pycnogenol
- What it is
- Standardized French maritime pine-bark extract.
- Hormone?
- Not a hormone.
- Why it's here
- Its specific added benefit in this compounded ED formula is less established than sildenafil.
Why choose this one?
Why choose this one
For men who want a wider timing window and prefer a dissolving format.
Why choose Sildenafil + Pycnogenol ODT or Vardenafil Troche instead?
Sildenafil or vardenafil may fit better if you want a shorter planned window and less time with medication in your system.
Compare your options
Sildenafil vs tadalafil
| Sildenafil (and vardenafil) | Tadalafil | |
|---|---|---|
| Treatment type | PDE5 inhibitor, shorter-acting | PDE5 inhibitor, longer-acting |
| Who it's for | Men | Men |
| Typical use | Taken about an hour before sex | Taken before sex, with a much longer window |
| How long it can work | Several hours | Still effective at 36 hours in a clinical study |
| Food | A large, high-fat meal can delay standard tablets | Absorption not meaningfully affected by food |
| Common side effects | Headache, flushing, indigestion, stuffy nose, vision tint | Headache, indigestion, back pain, muscle aches, flushing |
| Never combine with | Nitrate medicines | Nitrate medicines |
| Price at Avono | From $60 for 6 doses | From $60 for 6 doses |
Duration and food findings come from standard FDA-approved tablets. Compounded dissolving formats were not studied in those trials.
Tablet vs dissolving formats
| Standard tablet | ODT or troche | |
|---|---|---|
| How it's taken | Swallowed with water | Dissolves in the mouth |
| Evidence | The format used in the main clinical trials | Compounded formats were not themselves studied in those trials |
| Ingredients | A single medicine | Some combine a second ingredient |
| Who may prefer it | People who want the most-studied format | People who prefer not to swallow pills |
| Price at Avono | From $99 | From $60 for 6 doses |
Benefits and evidence
Tadalafil at 24 and 36 hours
- What the study found
- 36 hours
- Who was studied
- 348 men with erectile dysfunction
- What it means
- In a tadalafil 20 mg clinical study, treatment remained effective through the 36-hour assessment period.
- Important context
- Studied tadalafil 20 mg. These results do not automatically apply to compounded combination ODTs. Oral tadalafil · 20 mg · Assessed at about 24 and 36 hours after dosing
- Source
- Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial Urology, 2003, PMID 12837435
Common side effects
Headache, flushing, indigestion, nasal congestion, back pain, muscle aches and dizziness.
What may help
Headache, flushing and a stuffy nose are the most common side effects and are usually mild and short-lived. General measures that may help:
- Stay hydrated, and keep alcohol moderate; heavy drinking makes dizziness and low blood pressure more likely and can itself worsen erections.
- With standard sildenafil tablets, a large or high-fat meal can delay the effect.
- Do not take more than prescribed, and do not combine with other erection medicines.
If side effects bother you, your clinician can review the plan.
Important safety information
Do not use a PDE5 inhibitor with nitrate medications. The combination can cause a dangerous drop in blood pressure.
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Do not use with nitrates. Review cardiovascular history, alpha blockers/blood-pressure drugs, kidney/liver issues and other ED medications. Compounded combination, not FDA-approved.
This is a compounded medication. Compounded medications are prepared by licensed pharmacies and are not FDA-approved.
Prescription treatments require evaluation by a licensed clinician and are not appropriate for everyone. Some of these medications can interact with other medications, including nitrates. Compounded formulas are not FDA-approved. Not available in all states.
When to contact your clinician
Contact your clinician about fainting or significant dizziness, especially if you take blood-pressure medicines or alpha-blockers.
When to seek urgent care
Seek emergency care for an erection lasting more than 4 hours, sudden loss of vision in one or both eyes, sudden hearing loss (sometimes with ringing or dizziness), or chest pain during or after sex. Tell responders you took an erection medicine, because nitrates must not be given soon afterwards.
Questions people ask
Is tadalafil a hormone?
No. It is a PDE5 inhibitor.
Does tadalafil cause an automatic erection?
No. Sexual stimulation is still required.
Why is Pycnogenol included?
Pycnogenol is a standardized extract of French maritime pine bark. It contains polyphenolic compounds and has been studied for vascular/endothelial effects. The exact incremental benefit of adding it to a compounded ED medication is less established than the ED medication itself.
What does "up to 36 hours" mean?
It means the medication can support erectile response during that window when sexual stimulation occurs. It does not mean an erection lasts 36 hours.
What happens if I use nitrates?
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Does tadalafil really last 36 hours?
It can. In a study of tadalafil 20 mg, treatment was still effective at the 36-hour assessment: about 59% of attempts were successful versus 28% with placebo. "Lasting" means the window in which sexual stimulation can lead to an erection. It does not mean an erection lasts 36 hours.
Discuss Tadalafil + Pycnogenol ODT with a licensed clinician
Your clinician reviews your health history and decides whether this option, or another, is appropriate.
From $60 for 6 doses
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Tadalafil + Pycnogenol ODT From $60 for 6 doses