Sildenafil + Pycnogenol ODT
A dissolving compounded tablet pairing sildenafil with Pycnogenol, a pine-bark extract.
Active ingredients: Sildenafil + Pycnogenol
From $60 for 6 doses
- 6 doses $60
- 12 doses $99
- 18 doses $129
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Sildenafil is a well-established ED medication. This sildenafil + Pycnogenol compounded ODT is not FDA-approved as a combination product.
What it does
Sildenafil is the primary ED medication in the formula. Pycnogenol is a botanical extract studied for blood-vessel function, but its added benefit in this exact compounded combination is not established as clearly as sildenafil itself.
What's in it
Sildenafil
- What it is
- PDE5 inhibitor.
- Hormone?
- Not a hormone.
- Why it's here
- Improves blood-flow signaling during sexual stimulation.
Pycnogenol
- What it is
- Standardized French maritime pine-bark extract.
- Hormone?
- Not a hormone.
- Why it's here
- Its specific added benefit in this compounded ED formula is less established than sildenafil.
Why choose this one?
Why choose this one
For men who want a shorter, planned ED treatment window and prefer a dissolving format.
Why choose Tadalafil Tablet instead?
Tadalafil lasts much longer and may fit better if you want less precise timing around sex.
Compare your options
Sildenafil vs tadalafil
| Sildenafil (and vardenafil) | Tadalafil | |
|---|---|---|
| Treatment type | PDE5 inhibitor, shorter-acting | PDE5 inhibitor, longer-acting |
| Who it's for | Men | Men |
| Typical use | Taken about an hour before sex | Taken before sex, with a much longer window |
| How long it can work | Several hours | Still effective at 36 hours in a clinical study |
| Food | A large, high-fat meal can delay standard tablets | Absorption not meaningfully affected by food |
| Common side effects | Headache, flushing, indigestion, stuffy nose, vision tint | Headache, indigestion, back pain, muscle aches, flushing |
| Never combine with | Nitrate medicines | Nitrate medicines |
| Price at Avono | From $60 for 6 doses | From $60 for 6 doses |
Duration and food findings come from standard FDA-approved tablets. Compounded dissolving formats were not studied in those trials.
Tablet vs dissolving formats
| Standard tablet | ODT or troche | |
|---|---|---|
| How it's taken | Swallowed with water | Dissolves in the mouth |
| Evidence | The format used in the main clinical trials | Compounded formats were not themselves studied in those trials |
| Ingredients | A single medicine | Some combine a second ingredient |
| Who may prefer it | People who want the most-studied format | People who prefer not to swallow pills |
| Price at Avono | From $99 | From $60 for 6 doses |
Benefits and evidence
Sildenafil placebo-controlled study
- What the study found
- 74% vs 16%
- Who was studied
- 329 men with erectile dysfunction
- What it means
- In a placebo-controlled sildenafil study, 74% of participants reported improved erections compared with 16% receiving placebo.
- Important context
- Studied oral sildenafil. The compounded sildenafil + Pycnogenol ODT was not itself studied. Oral sildenafil · Flexible oral dosing · 12 weeks
- Source
- Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double-blind, placebo-controlled study of 329 patients. Sildenafil Study Group International Journal of Clinical Practice, 1998, PMID 9894373
Common side effects
Headache, flushing, indigestion, nasal congestion, dizziness and temporary visual color/brightness changes can occur.
What may help
Headache, flushing and a stuffy nose are the most common side effects and are usually mild and short-lived. General measures that may help:
- Stay hydrated, and keep alcohol moderate; heavy drinking makes dizziness and low blood pressure more likely and can itself worsen erections.
- With standard sildenafil tablets, a large or high-fat meal can delay the effect.
- Do not take more than prescribed, and do not combine with other erection medicines.
If side effects bother you, your clinician can review the plan.
Important safety information
Do not use a PDE5 inhibitor with nitrate medications. The combination can cause a dangerous drop in blood pressure.
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Do not use with nitrates. Seek emergency care for an erection lasting more than 4 hours. Sudden vision or hearing loss requires prompt medical attention. Compounded combination, not FDA-approved.
This is a compounded medication. Compounded medications are prepared by licensed pharmacies and are not FDA-approved.
Prescription treatments require evaluation by a licensed clinician and are not appropriate for everyone. Some of these medications can interact with other medications, including nitrates. Compounded formulas are not FDA-approved. Not available in all states.
When to contact your clinician
Contact your clinician about fainting or significant dizziness, especially if you take blood-pressure medicines or alpha-blockers.
When to seek urgent care
Seek emergency care for an erection lasting more than 4 hours, sudden loss of vision in one or both eyes, sudden hearing loss (sometimes with ringing or dizziness), or chest pain during or after sex. Tell responders you took an erection medicine, because nitrates must not be given soon afterwards.
Questions people ask
Is Pycnogenol a hormone?
No. It is a botanical pine-bark extract.
Why is Pycnogenol included?
Pycnogenol is a standardized extract of French maritime pine bark. It contains polyphenolic compounds and has been studied for vascular/endothelial effects. The exact incremental benefit of adding it to a compounded ED medication is less established than the ED medication itself.
Does it increase libido?
No. PDE5 inhibitors are not aphrodisiacs. They do not create sexual desire on their own; they support erectile response during sexual stimulation.
How is tadalafil different from sildenafil?
Duration is the clearest practical difference. Tadalafil usually requires less precise timing because of its longer half-life/duration. Sildenafil is generally used closer to planned sexual activity and has a shorter duration.
What happens if I use nitrates?
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Why does sildenafil sometimes take longer to work?
With standard sildenafil tablets, a large or high-fat meal can slow absorption and delay the effect. How food affects compounded dissolving formats has been studied less. Sexual stimulation is still needed.
Discuss Sildenafil + Pycnogenol ODT with a licensed clinician
Your clinician reviews your health history and decides whether this option, or another, is appropriate.
From $60 for 6 doses
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Sildenafil + Pycnogenol ODT From $60 for 6 doses