Tadalafil Tablet
A single-ingredient, longer-acting ED tablet with a treatment window of up to 36 hours in standard clinical use.
Active ingredients: Tadalafil
$99
No membership fee · No clinician fee · Free shipping
Your secure clinical intake will open in a new tab.
Tadalafil is an FDA-approved ED medication in standard tablet formulations.
What it does
Tadalafil inhibits PDE5 and helps blood-flow signaling support an erection during sexual stimulation. It does not cause a continuous erection and does not create sexual desire.
What's in it
Tadalafil
- What it is
- Longer-acting PDE5 inhibitor.
- Hormone?
- Not a hormone.
- Why it's here
- Supports erectile response during sexual stimulation and can provide a longer timing window.
Why choose this one?
Why choose this one
For men who want more flexibility around timing and a simple single-ingredient tablet.
Why choose Sildenafil + Pycnogenol ODT or Vardenafil Troche instead?
Sildenafil or vardenafil may fit better if you prefer a shorter planned treatment window.
Compare your options
Sildenafil vs tadalafil
| Sildenafil (and vardenafil) | Tadalafil | |
|---|---|---|
| Treatment type | PDE5 inhibitor, shorter-acting | PDE5 inhibitor, longer-acting |
| Who it's for | Men | Men |
| Typical use | Taken about an hour before sex | Taken before sex, with a much longer window |
| How long it can work | Several hours | Still effective at 36 hours in a clinical study |
| Food | A large, high-fat meal can delay standard tablets | Absorption not meaningfully affected by food |
| Common side effects | Headache, flushing, indigestion, stuffy nose, vision tint | Headache, indigestion, back pain, muscle aches, flushing |
| Never combine with | Nitrate medicines | Nitrate medicines |
| Price at Avono | From $60 for 6 doses | From $60 for 6 doses |
Duration and food findings come from standard FDA-approved tablets. Compounded dissolving formats were not studied in those trials.
Tablet vs dissolving formats
| Standard tablet | ODT or troche | |
|---|---|---|
| How it's taken | Swallowed with water | Dissolves in the mouth |
| Evidence | The format used in the main clinical trials | Compounded formats were not themselves studied in those trials |
| Ingredients | A single medicine | Some combine a second ingredient |
| Who may prefer it | People who want the most-studied format | People who prefer not to swallow pills |
| Price at Avono | From $99 | From $60 for 6 doses |
Benefits and evidence
Tadalafil at 24 and 36 hours
- What the study found
- 36 hours
- Who was studied
- 348 men with erectile dysfunction
- What it means
- In a tadalafil 20 mg clinical study, treatment remained effective through the 36-hour assessment period.
- Important context
- Studied tadalafil 20 mg. These results do not automatically apply to compounded combination ODTs. Oral tadalafil · 20 mg · Assessed at about 24 and 36 hours after dosing
- Source
- Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial Urology, 2003, PMID 12837435
Common side effects
Headache, flushing, indigestion, nasal congestion, back pain, muscle aches and dizziness.
What may help
Headache, flushing and a stuffy nose are the most common side effects and are usually mild and short-lived. General measures that may help:
- Stay hydrated, and keep alcohol moderate; heavy drinking makes dizziness and low blood pressure more likely and can itself worsen erections.
- With standard sildenafil tablets, a large or high-fat meal can delay the effect.
- Do not take more than prescribed, and do not combine with other erection medicines.
If side effects bother you, your clinician can review the plan.
Important safety information
Do not use a PDE5 inhibitor with nitrate medications. The combination can cause a dangerous drop in blood pressure.
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Nitrates are contraindicated. Alpha blockers, antihypertensives, kidney/liver function and cardiovascular status may matter.
Prescription treatments require evaluation by a licensed clinician and are not appropriate for everyone. Some of these medications can interact with other medications, including nitrates. Compounded formulas are not FDA-approved. Not available in all states.
When to contact your clinician
Contact your clinician about fainting or significant dizziness, especially if you take blood-pressure medicines or alpha-blockers.
When to seek urgent care
Seek emergency care for an erection lasting more than 4 hours, sudden loss of vision in one or both eyes, sudden hearing loss (sometimes with ringing or dizziness), or chest pain during or after sex. Tell responders you took an erection medicine, because nitrates must not be given soon afterwards.
Questions people ask
Does "up to 36 hours" mean a 36-hour erection?
No. It means tadalafil can support erectile response during that window when sexual stimulation occurs.
Does 36 hours mean I have an erection for 36 hours?
No. It means the medication can support erectile response during that window when sexual stimulation occurs.
Is this a hormone?
No. Tadalafil is a PDE5 inhibitor, not a hormone.
Does it increase libido?
No. PDE5 inhibitors are not aphrodisiacs. They do not create sexual desire on their own; they support erectile response during sexual stimulation.
What happens if I use nitrates?
PDE5 inhibitors must not be used with nitrate medications because the combination can cause dangerous blood-pressure lowering. Other cardiovascular history, alpha blockers and interacting drugs matter.
Does tadalafil really last 36 hours?
It can. In a study of tadalafil 20 mg, treatment was still effective at the 36-hour assessment: about 59% of attempts were successful versus 28% with placebo. "Lasting" means the window in which sexual stimulation can lead to an erection. It does not mean an erection lasts 36 hours.
Discuss Tadalafil Tablet with a licensed clinician
Your clinician reviews your health history and decides whether this option, or another, is appropriate.
$99
Your secure clinical intake will open in a new tab.
Tadalafil Tablet $99